Review





Similar Products

lps  (MedChemExpress)
99
MedChemExpress lps
Lps, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/e%2E+coli+o55%3Ab5+lps/Lipopolysaccharides%2C+from+E%2E+coli+O55%3AB5/pmc13382133-24-0-2
Average 99 stars, based on 1 article reviews
lps - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier
lps lipopolysaccharide  (MedChemExpress)
99
MedChemExpress lps lipopolysaccharide
ZDHHC17 deficiency stimulates pro-inflammatory cytokines production in macrophages leading to enhanced expression of fibro-genic genes in HSCs (A) THP-1 cells were induced to M0 macrophages by PMA and further polarized to M1 macrophages by treatment with <t>LPS/IFN-γ.</t> ZDHHC17 was over-expressed or knocked down in M1 macrophages by plasmid transfection or siRNA. Cells were collected 48 h post-transfection for detection. LX2 cells were seeded onto the lower chamber, and M1 macrophages were plated on the upper chamber of a 0.4 μm transwell membrane, which prevents direct cell contact, limiting cell interaction to secretory chemicals. (B and C) ZDHHC17 was significantly overexpressed in M1 macrophages by plasmid transfection (B) and decreased by small interfering RNAs (siRNAs) (C). Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of the pro-inflammatory cytokines (TNF-α, IL-1β, and IL-12β) were detected in ZDHHC17-overexpressed (D) or ZDHHC17-silenced (E) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). ELISA detected serum TNF-α, IL-1β, and IL-12β in ZDHHC17-overexpressed (F) or ZDHHC17-silenced (G) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of α-SMA, COL1A1, TGF-β, and TIMP-1 was detected by qPCR in LX-2 cells following co-cultured with ZDHHC17-overexpressed (H) or silenced (I) macrophages. Data were presented as mean ± SD ( n = 6 independent experiments). ∗ p < 0.05 , ∗∗ p < 0.01 , ∗∗∗ p < 0.001 , ∗∗∗∗ p < 0.0001 by Student’s t test (B-I).
Lps Lipopolysaccharide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/e%2E+coli+o55%3Ab5+lps/Lipopolysaccharides%2C+from+E%2E+coli+O55%3AB5/pmc13378008-30-0-3
Average 99 stars, based on 1 article reviews
lps lipopolysaccharide - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier
lps solution  (MedChemExpress)
99
MedChemExpress lps solution
ZDHHC17 deficiency stimulates pro-inflammatory cytokines production in macrophages leading to enhanced expression of fibro-genic genes in HSCs (A) THP-1 cells were induced to M0 macrophages by PMA and further polarized to M1 macrophages by treatment with <t>LPS/IFN-γ.</t> ZDHHC17 was over-expressed or knocked down in M1 macrophages by plasmid transfection or siRNA. Cells were collected 48 h post-transfection for detection. LX2 cells were seeded onto the lower chamber, and M1 macrophages were plated on the upper chamber of a 0.4 μm transwell membrane, which prevents direct cell contact, limiting cell interaction to secretory chemicals. (B and C) ZDHHC17 was significantly overexpressed in M1 macrophages by plasmid transfection (B) and decreased by small interfering RNAs (siRNAs) (C). Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of the pro-inflammatory cytokines (TNF-α, IL-1β, and IL-12β) were detected in ZDHHC17-overexpressed (D) or ZDHHC17-silenced (E) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). ELISA detected serum TNF-α, IL-1β, and IL-12β in ZDHHC17-overexpressed (F) or ZDHHC17-silenced (G) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of α-SMA, COL1A1, TGF-β, and TIMP-1 was detected by qPCR in LX-2 cells following co-cultured with ZDHHC17-overexpressed (H) or silenced (I) macrophages. Data were presented as mean ± SD ( n = 6 independent experiments). ∗ p < 0.05 , ∗∗ p < 0.01 , ∗∗∗ p < 0.001 , ∗∗∗∗ p < 0.0001 by Student’s t test (B-I).
Lps Solution, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/e%2E+coli+o55%3Ab5+lps/Lipopolysaccharides%2C+from+E%2E+coli+O55%3AB5/pm42259237-60-13-16
Average 99 stars, based on 1 article reviews
lps solution - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier
lps group  (MedChemExpress)
99
MedChemExpress lps group
ZDHHC17 deficiency stimulates pro-inflammatory cytokines production in macrophages leading to enhanced expression of fibro-genic genes in HSCs (A) THP-1 cells were induced to M0 macrophages by PMA and further polarized to M1 macrophages by treatment with <t>LPS/IFN-γ.</t> ZDHHC17 was over-expressed or knocked down in M1 macrophages by plasmid transfection or siRNA. Cells were collected 48 h post-transfection for detection. LX2 cells were seeded onto the lower chamber, and M1 macrophages were plated on the upper chamber of a 0.4 μm transwell membrane, which prevents direct cell contact, limiting cell interaction to secretory chemicals. (B and C) ZDHHC17 was significantly overexpressed in M1 macrophages by plasmid transfection (B) and decreased by small interfering RNAs (siRNAs) (C). Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of the pro-inflammatory cytokines (TNF-α, IL-1β, and IL-12β) were detected in ZDHHC17-overexpressed (D) or ZDHHC17-silenced (E) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). ELISA detected serum TNF-α, IL-1β, and IL-12β in ZDHHC17-overexpressed (F) or ZDHHC17-silenced (G) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of α-SMA, COL1A1, TGF-β, and TIMP-1 was detected by qPCR in LX-2 cells following co-cultured with ZDHHC17-overexpressed (H) or silenced (I) macrophages. Data were presented as mean ± SD ( n = 6 independent experiments). ∗ p < 0.05 , ∗∗ p < 0.01 , ∗∗∗ p < 0.001 , ∗∗∗∗ p < 0.0001 by Student’s t test (B-I).
Lps Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/e%2E+coli+o55%3Ab5+lps/Lipopolysaccharides%2C+from+E%2E+coli+O55%3AB5/pm42114306-113-14-8
Average 99 stars, based on 1 article reviews
lps group - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier
lipopolysaccharide lps  (MedChemExpress)
99
MedChemExpress lipopolysaccharide lps
ZDHHC17 deficiency stimulates pro-inflammatory cytokines production in macrophages leading to enhanced expression of fibro-genic genes in HSCs (A) THP-1 cells were induced to M0 macrophages by PMA and further polarized to M1 macrophages by treatment with <t>LPS/IFN-γ.</t> ZDHHC17 was over-expressed or knocked down in M1 macrophages by plasmid transfection or siRNA. Cells were collected 48 h post-transfection for detection. LX2 cells were seeded onto the lower chamber, and M1 macrophages were plated on the upper chamber of a 0.4 μm transwell membrane, which prevents direct cell contact, limiting cell interaction to secretory chemicals. (B and C) ZDHHC17 was significantly overexpressed in M1 macrophages by plasmid transfection (B) and decreased by small interfering RNAs (siRNAs) (C). Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of the pro-inflammatory cytokines (TNF-α, IL-1β, and IL-12β) were detected in ZDHHC17-overexpressed (D) or ZDHHC17-silenced (E) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). ELISA detected serum TNF-α, IL-1β, and IL-12β in ZDHHC17-overexpressed (F) or ZDHHC17-silenced (G) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of α-SMA, COL1A1, TGF-β, and TIMP-1 was detected by qPCR in LX-2 cells following co-cultured with ZDHHC17-overexpressed (H) or silenced (I) macrophages. Data were presented as mean ± SD ( n = 6 independent experiments). ∗ p < 0.05 , ∗∗ p < 0.01 , ∗∗∗ p < 0.001 , ∗∗∗∗ p < 0.0001 by Student’s t test (B-I).
Lipopolysaccharide Lps, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/e%2E+coli+o55%3Ab5+lps/Lipopolysaccharides%2C+from+E%2E+coli+O55%3AB5/pm42101758-41-36-41
Average 99 stars, based on 1 article reviews
lipopolysaccharide lps - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier

Image Search Results


ZDHHC17 deficiency stimulates pro-inflammatory cytokines production in macrophages leading to enhanced expression of fibro-genic genes in HSCs (A) THP-1 cells were induced to M0 macrophages by PMA and further polarized to M1 macrophages by treatment with LPS/IFN-γ. ZDHHC17 was over-expressed or knocked down in M1 macrophages by plasmid transfection or siRNA. Cells were collected 48 h post-transfection for detection. LX2 cells were seeded onto the lower chamber, and M1 macrophages were plated on the upper chamber of a 0.4 μm transwell membrane, which prevents direct cell contact, limiting cell interaction to secretory chemicals. (B and C) ZDHHC17 was significantly overexpressed in M1 macrophages by plasmid transfection (B) and decreased by small interfering RNAs (siRNAs) (C). Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of the pro-inflammatory cytokines (TNF-α, IL-1β, and IL-12β) were detected in ZDHHC17-overexpressed (D) or ZDHHC17-silenced (E) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). ELISA detected serum TNF-α, IL-1β, and IL-12β in ZDHHC17-overexpressed (F) or ZDHHC17-silenced (G) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of α-SMA, COL1A1, TGF-β, and TIMP-1 was detected by qPCR in LX-2 cells following co-cultured with ZDHHC17-overexpressed (H) or silenced (I) macrophages. Data were presented as mean ± SD ( n = 6 independent experiments). ∗ p < 0.05 , ∗∗ p < 0.01 , ∗∗∗ p < 0.001 , ∗∗∗∗ p < 0.0001 by Student’s t test (B-I).

Journal: iScience

Article Title: ZDHHC17-mediated IKKβ palmitoylation suppresses NF-κB signaling to mitigate the progression of liver fibrosis

doi: 10.1016/j.isci.2026.116360

Figure Lengend Snippet: ZDHHC17 deficiency stimulates pro-inflammatory cytokines production in macrophages leading to enhanced expression of fibro-genic genes in HSCs (A) THP-1 cells were induced to M0 macrophages by PMA and further polarized to M1 macrophages by treatment with LPS/IFN-γ. ZDHHC17 was over-expressed or knocked down in M1 macrophages by plasmid transfection or siRNA. Cells were collected 48 h post-transfection for detection. LX2 cells were seeded onto the lower chamber, and M1 macrophages were plated on the upper chamber of a 0.4 μm transwell membrane, which prevents direct cell contact, limiting cell interaction to secretory chemicals. (B and C) ZDHHC17 was significantly overexpressed in M1 macrophages by plasmid transfection (B) and decreased by small interfering RNAs (siRNAs) (C). Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of the pro-inflammatory cytokines (TNF-α, IL-1β, and IL-12β) were detected in ZDHHC17-overexpressed (D) or ZDHHC17-silenced (E) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). ELISA detected serum TNF-α, IL-1β, and IL-12β in ZDHHC17-overexpressed (F) or ZDHHC17-silenced (G) macrophages. Data are presented as the mean ± SD ( n = 6 independent experiments). mRNA expression of α-SMA, COL1A1, TGF-β, and TIMP-1 was detected by qPCR in LX-2 cells following co-cultured with ZDHHC17-overexpressed (H) or silenced (I) macrophages. Data were presented as mean ± SD ( n = 6 independent experiments). ∗ p < 0.05 , ∗∗ p < 0.01 , ∗∗∗ p < 0.001 , ∗∗∗∗ p < 0.0001 by Student’s t test (B-I).

Article Snippet: LPS (Lipopolysaccharide) , MCE (Monmouth Junction, NJ, USA) , Cat# HY-D1056.

Techniques: Expressing, Plasmid Preparation, Transfection, Membrane, Enzyme-linked Immunosorbent Assay, Cell Culture